Pesticidal compositions containing rosemary oil and wintergreen oil

ABSTRACT

Pesticidal compositions containing plant essential oils, such as rosemary oil and/or wintergreen oil, and methods for using same are disclosed.

CROSS-REFERENCE TO RELATED APPLICATIONS

This continuing application is a divisional of U.S. application Ser. No.13/755,958, filed Jan. 31, 2013, which is a divisional of U.S.application Ser. No. 12/872,725, filed Aug. 31, 2010, which is adivisional of U.S. application Ser. No. 11/746,927, filed May 10, 2007,which is a continuation of U.S. application Ser. No. 10/014,797, filedDec. 14, 2001, which (1) is a continuation-in-part of U.S. applicationSer. No. 09/604,082, filed Jun. 27, 2000, which claims the benefit ofU.S. Provisional Application Ser. No. 60/140,845, filed Jun. 28, 1999,the entire disclosure of which is incorporated herein by reference, (2)is a continuation-in-part of U.S. application Ser. No. 09/505,680, filedFeb. 17, 2000, the entire disclosure of which is incorporated herein byreference and (3) is a continuation-in-part of U.S. application Ser. No.09/340,391, filed Jun. 28, 1999, now U.S. Pat. No. 6,986,898, which inturn claims the benefit of U.S. Provisional Patent Application No.60/094,463, filed Jul. 28, 1998, U.S. Provisional Patent ApplicationSer. No. 60/100,613, filed Sep. 16, 1998, and U.S. Provisional PatentApplication Ser. No. 60/122,803, filed Mar. 3, 1999, the entiredisclosures of each of the above-referenced patent applications areincorporated herein by reference. For avoidance of doubt, thiscontinuing application claims the benefit of each of theabove-identified patent applications.

FIELD OF THE INVENTION

The present invention relates to novel pesticidal compositions andmethods for using same for the control of pests.

BACKGROUND OF THE INVENTION

Pests are annoying to humans for several reasons. Pests includepathogenic organisms which infest mammals and plants; some pests canspread disease as disease vectors. The pathogenic organisms that infestplants and cause economic loss of plant crops include fungi, insects,arachnids, gastropods, nematodes and the like. The pathogenic organismsthat infest animals include ticks, mites, fleas, and mosquitoes. Otherpests include cockroaches, termites and ants. These and other pests haveannually cost humans billions of dollars in crop losses in the case ofagricultural pests and in the expense of keeping them under control. Forexample, the losses caused by pests in agricultural environments includedecreased crop yield, reduced crop quality, and increased harvestingcosts. In household scenarios, insect pests may act as vectors fordiseases and allergic matter.

Over the years, synthetic chemical pesticides have provided an effectivemeans of pest control. For example, one approach teaches the use ofcomplex, organic insecticides, such as disclosed in U.S. Pat. Nos.4,376,784 and 4,308,279. Other approaches employ absorbent organicpolymers for widespread dehydration of the insects. See, U.S. Pat. Nos.4,985,251; 4,983,390; 4,818,534; and 4,983,389. Use of inorganic saltsas components of pesticides has also been tried, as disclosed in U.S.Pat. Nos. 2,423,284 and 4,948,013, European Patent Application No. 462347, Chemical Abstracts 119(5):43357q (1993) and Farm ChemicalsHandbook, page c102 (1987).

However, it has become increasingly apparent that the widespread use ofsynthetic chemical pesticides has caused detrimental environmentaleffects that are harmful to humans and other animals. For instance, thepublic has become concerned about the amount of residual chemicals thatpersist in food, ground water and the environment, and that are toxic,carcinogenic or otherwise incompatible to humans, domestic animalsand/or fish. Moreover, some target pests have even shown an ability todevelop resistance to many commonly used synthetic chemical pesticides.In recent times, regulatory guidelines have encouraged a search forpotentially less dangerous pesticidal compositions via stringentrestrictions on the use of certain synthetic pesticides. As a result,elimination of effective pesticides from the market has limitedeconomical and effective options for controlling pests. As analternative, botanical pesticides are of great interest because they arenatural pesticides, i.e., toxicants derived from plants that are safe tohumans and the environment. Use of food-grade plant essential oils havebeen tried, as described in U.S. Pat. Nos. 5,439,690, 5,693,344,6,004,569, 6,114,384, and 6,183,767 B1. However, these plant essentialoils when used alone can be expensive, impractical or ineffective undercertain circumstances.

Accordingly, there is a great need for novel pesticidal compositionscontaining no pyrethrum, synthetic pyrethroids, chlorinatedhydrocarbons, organo phosphates, carbamates and the like, but comprisingfood-grade plant essential oils, to be used against invertebrate pests,including insects, arachnids, larvae and eggs thereof. In addition,there is a need for a method of treating a locus to be protected to killand repel invertebrate pests.

SUMMARY OF THE INVENTION

A primary object of the present invention is to provide novel pesticidalcompositions for use against pests such as invertebrate insects,arachnids, larvae and eggs thereof.

Another object of the invention is to provide novel pesticidalcompositions containing rosemary oil and/or wintergreen oil as a contactand repellent pesticide in household applications.

Another object of the invention is to provide novel pesticidalcompositions containing rosemary oil and/or wintergreen oil as a contactand repellent pesticide in lawn and garden applications.

Another object of the invention is to provide novel pesticidalcompositions containing rosemary oil and/or wintergreen oil as a contactand repellent pesticide in greenhouse and nursery applications.

Another object of the invention is to provide novel pesticidalcompositions containing rosemary oil and/or wintergreen oil as a contactand repellent pesticide in agricultural applications.

Another object of the invention is to provide novel pesticidalcompositions containing rosemary oil and/or wintergreen oil as a contactpesticide against various stages of the lifecycle of invertebrate pests,including eggs, nymphs, pupae and adults.

Another object of the invention is to provide novel pesticidalcompositions containing rosemary oil and/or wintergreen oil that can beused with conventional pesticides, including conventional plantessential oils such as thyme oil, eugenol and 2-phenethyl propionate,and conventional synergists such as piperonyl butoxide.

It is also an object of the present invention to provide a method oftreating a locus where invertebrate pest control is desired.

It is also an object of the present invention to provide a pesticidalcomposition and method for mechanically and neurally controllinginvertebrate pests.

It is a further object to provide a safe, pesticidal composition andmethod that will not harm mammals or the environment.

It is still another object to provide a pesticidal composition andmethod that has a pleasant scent, but is not too strong or lingering,and that can be applied without burdensome safety precautions.

It is still another object to provide a pesticidal composition andmethod as described above which can be inexpensively produced oremployed.

It is still another object to provide a pesticidal composition andmethod as described above which can be used indoors and outdoors andwill not soften, dissolve, or otherwise adversely affect treatedsurfaces.

It is still another object to provide a pesticidal composition andmethod as described above which is exempt from registration with theU.S. Environmental Protection Agency under the Federal Insecticide,Fungicide and Rodenticide Act.

It is still another object to provide a pesticidal compostioin that isnon-phytotoxic and can be safely applied to economically valuable plantsor crops.

It is still another object to provide a pesticidal composition andmethod as described above which is exempt from a food tolerance residuerequirement when used on food under the Federal Food and Drug CosmeticAct.

It is still another object to provide a pesticidal composition andmethod as described above which is allowed in organic farming under theOrganic Materials Review Institute and the National Organic Program.

It is yet another object of the invention to provide a pesticidalcomposition and method to which invertebrate pests can not buildresistance.

It is yet another object of the invention to provide a pesticidalcomposition and method to provide quick knockdown and kill ofinvertebrate pests, particularly in household applications.

It is yet another object of the invention to provide a pesticidalcomposition and method as described above that can be formulated as awater-based emulsion, some of which may be exempt from registration withthe U.S. EPA.

One or more of the above non-limiting objects and technical effects areaccomplished by the present invention, which is directed to pesticidalcompositions comprising rosemary oil and/or wintergreen oil. Inaddition, the present invention is directed to a method for controllingpests by applying a pesticidally-effective amount of the pesticidalcompositions of the present invention to a location where pest controlis desired. The pesticidal compositions of the represent invention canbe applied and used as liquid sprays, crystals, gels, and pellets,impregnating material, such as posts, etc.

As used herein, the term “rosemary oil” denotes both extracted andsynthetic versions of Rosmarinus officinalis, Limonium vulgare,Andromeda polifolia, and derivatives thereof, having at least one of thefollowing constituents: alpha-terpineol, beta-caryophyllene, borneol,bornyl acetate, bornyl acetate, camphene, camphor, cineole, diosmetin,diosmin, diterpenes, flavonoids including apigenin, genkwanin,hispidulin, isobutyl acetate, limonene, linalool, lutiolin, octanone,phenolic acids (Rosmarinic acid), pinene, saponincineole, sinensetin,terpinen-4-ol, thujone, and/or verbenol.

As used herein, the term “wintergreen oil” (Oil of Gaultheriaprocumbens) denotes both extracted (by distillation of the leaves ofGaultheria fragrantissima Wall) and synthetic versions (e.g., methylsalicylate) and derivatives thereof, including, without limitation,O-hydroxybenzoic acid methyl ester; Betula oil; salicylic acid, methylester; benzoic acid, 2-hydroxy-, methyl ester (2-HOC₆H₄COOCH₃) (CAS Nos.119-36-8 and 68917-75-9); sweet birch oil; Gaultheria oil; methylhydroxybenzoate; O-hydroxybenzoate; 2-(methoxycarbonyl)phenol;2-carbomethoxyphenol; Linsal; methylester kyseliny salicylove (Czech);o-anisic acid; panalgesic; methyl o-hydroxybenzoate; teaberry oil;analgit; exagien; flucarmit; anthrapole nd; Metsal liniment, and thelike.

As used herein, the term “pest” refers to organisms and microorganisms,including pathogens, that negatively affect plants or animals bycolonizing, attacking or infecting them. This includes organisms thatspread disease and/or damage the host and/or compete for host nutrients.In addition, plant pests are organisms known to associate with plantsand which, as a result of that association, causes a detrimental effecton the plant's health and vigor. Plant pests include but are not limitedto fungi, bacteria, insects, and nematodes.

The term “pesticide” as used herein refers to a substance that can beused in the control of agricultural, natural environmental, anddomestic/household pests, such as insects, fungi, bacteria, and viruses.The term “pesticide” is understood to encompass naturally occurring orsynthetic chemical insecticides (larvicides, and adulticides), insectgrowth regulators, acaricides (miticides), nematicides,ectoparasiticides, bactericides, fungicides, and herbicides (substancewhich can be used in agriculture to control or modify plant growth).

The term “plant” as used herein encompasses whole plants and parts ofplants such as roots, stems, leaves and seed, as well as cells andtissues within the plants or plant parts. Target crops to be protectedwithin the scope of the present invention include, without limitation,the following species of plants: cereals (wheat, barley, rye, oats,rice, sorghum and related crops), beet (sugar beet and fodder beet),forage grasses (orchardgrass, fescue, and the like), drupes, pomes andsoft fruit (apples, pears, plums, peaches, almonds, cherries,strawberries, raspberries and blackberries), leguminous plants (beans,lentils, peas, soybeans), oil plants (rape, mustard, poppy, olives,sunflowers, coconuts, castor oil plants, cocoa beans, groundnuts),cucumber plants (cucumber, marrows, melons) fiber plants (cotton, flax,hemp, jute), citrus fruit (oranges, lemons, grapefruit, mandarins),vegetables (spinach, lettuce, asparagus, cabbages and other Brassicae,onions, tomatoes, potatoes, paprika), lauraceae (avocados, carrots,cinnamon, camphor), deciduous trees and conifers (e.g. linden-trees,yew-trees, oak-trees, alders, poplars, birch-trees, firs, larches,pines), or plants such as maize, tobacco, nuts, coffee, sugar cane, tea,vines, hops, bananas and natural rubber plants, as well as ornamentals(including composites).

The terms “control” or “controlling” used throughout the specificationand claims, are meant to include any pesticidal (killing) or pestistatic(inhibiting, maiming or generally interfering) activities of apesticidal composition against a given pest. Thus, these terms not onlyinclude killing, but also include such activities as those ofchemisterilants which produce sterility in insects by preventing theproduction of ova or sperm, by causing death of sperm or ova, or byproducing severe injury to the genetic material of sperm or ova, so thatthe larvae that are produced do not develop into mature progeny. Theterms also include repellant activity that protect animals, plants orproducts from insect attack by making food or living conditionsunattractive or offensive to pests. These repellant activities may bethe result of repellents that are poisonous, mildly toxic, ornon-poisonous to pests.

The pesticidal compositions of the present invention may be used in thecontrol of agricultural, natural environmental, and domestic/householdpests, such as invertebrate insects, arachnids, larvae and eggs thereof,as well as against fungi, bacteria, and viruses.

In one aspect, the present invention relates to pesticidal compositionscontaining rosemary oil and/or wintergreen oil against household pestsincluding but not limited to cockroaches, ants, flies and spiders.

In another aspect, the present invention relates to pesticidalcompositions containing rosemary oil and/or wintergreen oil againstplant pests, including but not limited to mites, aphids, thrips,whiteflies, loopers, worms, beetles, leafrollers, moths and weevils.

In still another aspect, the present invention relates to pesticidalcompositions comprising rosemary oil and/or wintergreen oil to be usedas a contact pesticide against invertebrates such as insects, arachnids,larvae and eggs thereof.

In a further aspect, the present invention relates to pesticidalcompositions comprising rosemary oil and/or wintergreen oil to be usedas a repellent pesticide against invertebrate pests, and provideanti-feedant properties against plant pests in particular.

The present invention also relates to pesticidal compositions comprisingrosemary oil and/or wintergreen oil in combination with diluents such asmineral oil (e.g., paraffin oil; liquid petrolatum; white mineral oil;Nujol, alboline; bayol F; blandlube; drakeol; cutting oil; heat-treatingoil; hydraulic oil; transformer oil; lubricating oil; drawing oil;crystol 325, CAS Nos. 8012-95-1, 64742-46-7, 39355-35-6, 79956-36-8,83046-05-3), d-limonene, safflower oil, citronellal and sesame oil.

The present invention further relates to various optimum ratios betweenand among the constituents of each proprietary blend and the properdelivery system for each blend. For instance, the mixing ratio ofrosemary oil to wintergreen oil is the ratio wherein rosemary oil andwintergreen oil show a synergistic effect, and usually is from 100:1 to1:100 parts by weight, preferably within the range from 13:1 to 1:13.

The present invention also relates to pesticidal compositions containingrosemary oil and/or wintergreen oil that can be used with conventionalpesticides. For example, the conventional pesticide may be a memberselected from the group consisting of chlorinated hydrocarbon, syntheticpyrethroid, organo phosphate, carbamate, macrolide, insect growthregulator, neonicitinoid, organo-tin, and propargite. Further,conventional pesticide may be a member selected from the groupconsisting of allethrin, azadirachtin (neem), carbaryl, chlorpyrifos,DDT, fenvalorate, malathion, permethrin, pyrethrum, resmethrin, rotenoneand pyrethroid. The conventional pesticide may also be a member selectedfrom the group consisting of pyrethrolone, allethrolone, chrysanthemicacid, chrysanthemyl alcohol, cis-jasmone, and dimethyl sulfoxide (DMSO).

In a further aspect, the present invention relates to a method forcontrolling invertebrates such as insects, arachnids, larvae and eggsthereof, including but not limited to cockroaches, ants, flies, spiders,mites, aphids, thrips, whiteflies, loopers, worms, beetles, leafrollers,moths and weevils, by the application of pesticidally effective amountsof the pesticidal compositions of the present invention to a locationwhere invertebrate pest control is desired.

At least one of the above objects and advantages may be realized andattained by means of the instrumentalities and combinations particularlyrecited in the appended claims and/or supported by this writtendescription. Additional objects and attendant advantages of the presentinvention will be set forth, in part, in the description that follows,or may be learned from practicing or using the present invention. It isto be understood that the foregoing general description and thefollowing detailed description are exemplary and explanatory only andare not to be viewed as being restrictive of the invention, as claimed.

BRIEF DESCRIPTION OF THE DRAWINGS

The accompanying drawings, which are incorporated in and constitute apart of the specification, illustrates the present invention and,together with the description, serves to exemplify the principles of thepresent invention.

FIGS. 1-11 depict data obtained from comparative studies of HEXACIDE™(DR-A-034) and conventional pesticides.

FIG. 12 depicts data obtained from a comparison of the broad foliarfungicidal activities of DR-A-041 and Rhodafac RE 610.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

All patents, patent applications and literatures cited in thisdescription are incorporated herein by reference in their entirety.

The inventors have surprisingly found that the pesticidal compositionscontaining rosemary oil and/or wintergreen oil have a broad spectrum ofactivity and are particularly effective against, but not limited to,insects having a cuticle or proteinaceous exoskeleton or the like.Furthermore, the composition according to the present invention,comprises additional natural or essential oils as additional componentsand is therefore particularly advantageous in terms of its relativenon-toxicity.

The present invention provides very efficacious pesticides that, in apreferred aspect, may be designated as biopesticides in that theycomprise a chemical substance of natural origin that can be synthesized.The preferred pesticidal composition of the present invention have alethal effect on pest targets. Unlike the bulk of currently availablepesticides on the market, the preferred pesticidal compositions haveactive ingredients that have been proven to be substantially non-toxicto man and domestic animals and which have minimal adverse effects onwildlife and the environment.

The pesticidal compositions of the present invention are advantageous inthat they can typically control pests at average or lower than averagedosage rates. Such pesticidal compositions are also advantageous in thatthey can provide extended protection to a locus. Further, suchpesticidal compositions are also advantageous in that said pesticidalcompositions control pests without introducing a notable amount of harmto the surrounding environment of which the provided pesticidalcomposition is being utilized.

The pesticidal compositions of the invention have pesticidal activityagainst one or more pests. However, it is understood that certainpesticidal compositions may be more effective on some pests than others,and may even be ineffective against some pests. However, that does notin any way detract from their value as pesticides since the presentinvention contemplates use as broad, general acting pesticides, whileothers have utility as specific or selective pesticides. Thenon-limiting Examples set forth below illustrate methods by which thebroad-acting or selectivity of pesticidal activity may be readilyascertained by routine experimentation.

The pesticidal compositions of the present invention offer severaladvantages over currently used pesticides. First, the preferredessential oils used in the composition of the invention are naturallyoccurring compounds, and as such are relatively nontoxic to humans,domestic animals and wildlife. Consequently, when used for treatingplant pests, food crops can be treated using the composition up to andimmediately before the harvesting period, a practice that generally isavoided when using conventional methods of pest control. The compositionalso can be used to control the growth of pest organisms on harvestedcrops. The harvested food can be used directly as food for animals orhumans with little fear of (residual toxicity) or phytotoxicity. Byusing the subject compositions, the environmental and health hazardsinvolved in pest control are minimized. Because of the versatility andbroad spectrum of the present composition, when necessary, thecomposition can be used as a preventative on a repeated basis and, thus,can be integrated into integrated pest management (IPM) programs. Thecomposition can be applied to skin or to objects such as clothing, fur,feathers, or hair that come into contact with skin when used to treatpests that infest animals. The essential oils, i.e., the activeingredients, of the pesticidal compositions of the present invention arebelieved to be biorational chemicals that may qualify for the US EPABiopesticide Program.

Another advantage of the pesticidal compositions of the presentinvention is that they have not previously been used againstmicroorganisms, and therefore, fungal and bacterial pathogens and otherpest organisms have not acquired resistance to them. Disease resistanceto chemicals other than the heavy metals occurs commonly in pests suchas fungi and on rare occasions in bacterial plant disease pests. A newpesticide often becomes noticeably less effective against a particulardisease after several growing seasons. As pesticides become morespecific for diseases, the pests become resistant. This can beattributed to the singular mode of action of a particular pesticide,which disrupts only one genetically controlled process in the metabolismof the pest organism. The result is that resistant populations appearsuddenly, either by selection of resistant individuals in a populationor by a single gene mutation. Generally, the more specific the site andmode of a pesticidal action, the greater the likelihood for a pestorganism to develop a tolerance to that chemical. A new composition willsolve the disease resistance problem. To avoid developing future diseaseresistance in pests, different chemicals should be alternated fortreatment with the methods of the invention.

Methods of using the pesticidal compositions of the present inventionoffer several advantages over existing methods of pest control. Theformulations of the subject invention provide for effective control of(microorganisms) insects, mites, fungiand microorganisms In particularsituations, such as where an insect damages a plant part or tissue and asecondary fungal disease develops, this aspect of the invention isparticularly advantageous. The pesticidal compositions according to theinvention have very good fungicidal properties and can be employed forcontrolling phytopathogenic fungi, such as, without limitation,plasmodiophoromycetes, oomycetes, chytridiomycetes, zygomycetes,ascomycetes, basidiomycetes, deuteromycetes, etc. Fungal phytopathogensparticularly associated with crop plants and included within the scopeof the present invention include, without limitation, the following:Miscellaneous Fungal Diseases (e.g., Septoria tritici, Septorianodorum); Gibberella ear mold (e.g., e.g., Gibberella zeae, G.saubinetti); Aspergillus ear rot (e.g., Aspergillus flavus, A.parasiticus); Diplodia ear rot (e.g., Diplodia maydis, D. macrospora);Fusarium ear rot (e.g., Fusarium moniliforme, F. monilif. var.subglutinans); Pythium stalk rot (e.g., Pythium aphanidermata);Anthracnose stalk rot (e.g., Colletotrichum graminicola, C.tucumanensis, Glomerella graminicola); Diplodia stalk rot (e.g.,Diplodia maydis, D. zeae-maydis, Stenocarpella maydis, Macrodiplodiazeae, Sphaeria maydis, S. zeae, D. macrospora); Fusarium stalk rot(e.g., Fusarium moniliforme); Gibberella stalk rot (e.g., G. zeae, G.saubinetti); Stewart's wilt & leaf blight (e.g., Erwinia stewartii);Northern corn leaf blight (e.g., Exserohilum turcicum); Southern cornleaf blight (e.g., Bipolaris maydis); Gray leaf spot (e.g., Cercosporazeae-maydis, C. sorghi var. maydis); Anthracnose leaf blight (e.g.,Colletotrichum graminicola); Common rust (e.g., Puccinia sorghi, P.maydis); Southern rust (e.g., Puccinia polysora, Dicaeoma polysorum);Head smut (e.g., Sphacelotheca reiliana); Common smut (e.g., Ustilagomaydis); Carbonum leaf spot (e.g., Helminthosporium carbonum); Eye spot(e.g., Kabatiella zeae); Sorghum downy mildew (e.g., Peronosclerosporasorghi); Brown stripe downy mildew (e.g., Sclerophthora rayssiae);Sugarcane downy mildew (e.g., Peronosclerospora sacchari); Phillipinedowny mildew (e.g., Peronoscler. Philippinensis); Java downy mildew(e.g., Peronosclerospora maydis); Spontaneum downy mildew (e.g.,Peronosclerospora spantanea); Rajasthan downy mildew (e.g.,Peronosclerospora heteropogoni); Graminicola downy mildew (e.g.,Sclerospora graminicola); Rusts (e.g., Puccinia graminis f.sp. tritici,Puccinia recondita f.sp. tritici, Puccinia striiformis); Smuts (e.g.,Tilletia tritici, Tilletia controversa, Tilletia indica, Ustilagotritici, Urocystis tritici); Root rots, Foot rots and Blights (e.g.,Gaeumannomyces graminis, Pythium spp., Fusarium culmorum, Fusariumgraminaerum, Fusarium avenaceum, Drechslere tritici-repentis,Rhizoctonia spp., Colletotrichum graminicola, Helminthosporium spp.,Microdochium nivale, Pseudocercosporella herpotrichoides); Mildews(e.g., Erysiphe graminis f.sp. tritici, Sclerophthora macrospora), andthe like.

The long term control of pests results in plants with an improvedquality and yields of produce by host plants as compared with untreatedplants. The low concentration and single dose of anti-pest agentsdecreases the likelihood of damage to the plant and/or its crop, anddecreases the likelihood of adverse side effects to workers applying thepesticide, or to animals, fish or fowl which ingest the tissues or partsof treated plants. The methods of use of the pesticidal compositions ofthe invention will depend at least in part upon the pest to be treatedand its feeding habits, as well as breeding and nesting habits. Whilevery minor dosage rates of the novel compositions will have an adverseeffect on pests, adequate control usually involves the application of asufficient amount to either eliminate pests entirely or significantlydeter their growth and/or rate of proliferation. Dosage rates requiredto accomplish these effects, of course, vary depending on the targetpest, size, and maturity, i.e., stage of growth. More mature pests maybe more resistant to pesticides and require higher dosage rates for acomparable level of control. Dose response experiments using differentdilutions (for example, about 1:1000, 1:100, 1:10 and 1:3) of thepesticidal compositions of the present invention on target organisms andon plants are performed to determine the optimal concentration of theactive essential oil compound(s) that show(s) pesticidal activitywithout phytotoxicity or dermal sensitivity. For instance, when thepesticidal composition of the present invention is utilized foragricultural purposes, an amount from about 0.1 to 2,000 (SMB has aquestion mark by this) g/ha of the active ingredients is employed ontothe soil, plants, or directly onto the harmful pests, preferably as anemulsifiable concentrate or emulsion usually at a rate from 1 to 2000ppm.

In preferred embodiment, a pesticidal composition of the presentinvention useful for treating (e.g., preventing, controlling, impeding,and the like) infectious or pathogenic bacterial, viral, microbial, andother diseases causing pests is provided which includes applying aneffective amount of the pesticidal composition to a locus in needthereof for controlling, treating, managing, preventing, or the like,the spread of diseases caused by germs, bacteria, or viruses such asEscherichia coli, salmonella, staphylococci, streptococci, influenza,pneumonia, various blood and urine bacterial pathogens, and the like.The present invention further encompasses treatment of the following:gram-positive cocci that cause staphylococcal infections such aspneumonia, bacteremia, osteomyelitis, enterocolitis, and the like;streptococci that cause infections such as hemolytic, viridans,enterococci, lactic, and the like; pneumococci that cause infectionssuch as pneumonia, sinusitis, otitis, Meningitis, and the like;gram-negative cocci such as meningococcus, gonococcus, and the like;gram-positive bacilli that cause infections such as erysipelothricosis,listeriosis, anthrax, nocardiosis, and the like; gram-negative bacillithat cause infections such as enterobacteriaceac salmonella,shigellosis, hemophilus, tularemia, plaque, melioidosis, bartonellosis,campylobacter, and noncholera vibrio, and the like; anaerobic bacillithat cause infections such as clostridium botulinum, clostridium tetany,clostridia of gas gangrene bacteroides, mixed anaerobic, actinomycosis,and the like; mycobacteria that cause infections such as tuberculosisand leprosy, and the like; and spirochetes that cause diseases such asleptospirosis, lyme disease, and endemic treponematoses. Further, thepresent invention, the pesticidal compositions may be useful fortreating surfaces containing infectious human immunodeficiency virus(HIV), influenza, A, B, and C, parainfluenza viruses 1-4, rhonoviruses(common cold), mumps virus, adenoviruses, reoviruses, and epstein-Barrvirus, infants and adult syncytial virus, primary atypical pneumonia,polioviruses, coxsackieviruses, echoviruses and high numbered viruses,epidemic gastroenteritis viruses, rubeola virus, rubella virus,varicella-zoster virus, herpes simplex, human herpes virus type 6, humanparvovirus B19, cytomegalovirus, hepatitis viruses types A, B, C, D,human Papillomavirus, molluscum contagiosum virus, arboviruses,togaviruses, alphaviruses, flaviviruses, bunyaviruses, orbivirus, rabiesvirus, herpesvirus simiae, arenaviruses, filoviruses, and the like.

In a preferred embodiment, the present invention provides a pesticidalcomposition comprising rosemary oil and wintergreen oil in admixturewith mineral oil, lecithin and water. In this embodiment, rosemary oilis present in an amount of about 5-10%, wintergreen oil is present in anamount of about 20-45%, and mineral oil present in an amount of about20-45%.

In another embodiment, the present invention provides a pesticidalcomposition comprising rosemary oil and wintergreen oil in admixturewith mineral oil. In this embodiment, rosemary oil is present in anamount of about 5-20%, wintergreen oil is present in an amount of about20-80%, and mineral oil is present in an amount of about 5-45%.

In another embodiment, the present invention provides a pesticidalcomposition comprising rosemary oil and wintergreen oil in admixturewith thyme oil and mineral oil.

In another embodiment, the present invention provides a pesticidalcomposition comprising rosemary oil and wintergreen oil in admixturewith 2-phenethyl propionate and mineral oil.

In another embodiment, the present invention provides a pesticidalcomposition comprising rosemary oil and wintergreen oil in admixturewith 2-phenethyl propionate, safflower oil and mineral oil.

In another embodiment, the present invention provides a pesticidalcomposition comprising rosemary oil and wintergreen oil with a suitablecarrier and optionally with a suitable surface active agent, with andwithout one or more additional essential oil compounds and derivativesthereof, natural or synthetic, including racemic mixtures, enantiomers,diastereomers, hydrates, salts, solvates and metabolites, etc.Additional essential oils that may be included in the pesticidalcomposition of the present invention include, without limitation,members selected from the group consisting of α- or β-pinene;α-campholenic aldehyde; α-citronellol; α-iso-amyl-cinnamic (e.g., amylcinnamic aldehyde); α-pinene oxide; α-cinnamic terpinene; α-terpineol(e.g., methods. 1-methyl-4-isopropyl-1-cyclohexen-8-ol); λ-terpinene;achillea; aldehyde C16 (pure); alpha-phellandrene; amyl cinnamicaldehyde; amyl salicylate; anethole; anise; aniseed; anisic aldehyde;basil; bay; benzyl acetate; benzyl alcohol; bergamot (e.g., Monardiafistulosa, Monarda didyma, Citrus bergamia, Monarda punctata); bitterorange peel; black pepper; borneol; calamus; camphor; cananga oil (e.g.,java); cardamom; carnation (e.g., dianthus caryophyllus); carvacrol;carveol; cassia; castor; cedar (e.g., hinoki); cedarwood; chamomile;cineole; cinnamaldehyde; cinnamic alcohol; cinnamon; cis-pinane; citral(e.g., 3,7-dimethyl-2,6-octadienal); citronella; citronellal;citronellol dextro (e.g., 3-7-dimethyl-6-octen-1-ol); citronellol;citronellyl acetate; citronellyl nitrile; citrus unshiu; clary sage;clove (e.g., eugenia caryophyllus); clove bud; coriander; corn; cottonseed; d-dihydrocarvone; decyl aldehyde; diethyl phthalate;dihydroanethole; dihydrocarveol; dihydrolinalool; dihydromyrcene;dihydromyrcenol; dihydromyrcenyl acetate; dihydroterpineol; dimethylsalicylate; dimethyloctanal; dimethyloctanol; dimethyloctanyl acetate;diphenyl oxide; dipropylene glycol; d-limonene; d-pulegone; estragole;ethyl vanillin (e.g., 3-ethoxy-4-hydrobenzaldehyde); eucalyptol (e.g.,cineole); eucalyptus citriodora; eucalyptus globulus; eucalyptus;eugenol (e.g., 2-methoxy-4-allyl phenol); evening primrose; fenchol;fennel; ferniol.tm.; fish; florazon (e.g.,4-ethyl-α,α-dimethyl-benzenepropanal); galaxolide; geraniol (e.g.,2-trans-3,7-dimethyl-2,6-octadien-8-ol); geraniol; geranium; geranylacetate; geranyl nitrile; ginger; grapefruit; guaiacol; guaiacwood;gurjun balsam; heliotropin; herbanate (e.g.,3-(1-methyl-ethyl)bicyclo(2,2,1)hept-5-ene-2-carboxylic acid ethylester); hiba; hydroxycitronellal; i-carvone; i-methyl acetate; ionone;isobutyl quinoleine (e.g., 6-secondary butyl quinoline); isobornylacetate; isobornyl methylether; isoeugenol; isolongifolene; jasmine;jojoba; juniper berry; lavender; lavandin; lemon grass; lemon; lime;limonene; linallol oxide; linallol; linalool; linalyl acetate; linseed;litsea cubeba; l-methyl acetate; longifolene; mandarin; mentha; menthanehydroperoxide; menthol crystals; menthol laevo (e.g.,5-methyl-2-isopropyl cyclohexanol); menthol; menthone laevo (e.g.,4-isopropyl-1-methyl cyclohexan-3-one); methyl anthranilate; methylcedryl ketone; methyl chavicol; methyl hexyl ether; methyl ionone;mineral; mint; musk ambrette; musk ketone; musk xylol; mustard (alsoknown as allylisothio-cyanate); myrcene; nerol; neryl acetate; nonylaldehyde; nutmeg (e.g., myristica fragrans); orange (e.g., citrusaurantium dulcis); orris (e.g., iris florentina) root; para-cymene;para-hydroxy phenyl butanone crystals (e.g.,4-(4-hydroxyphenyl)-2-butanone); passion palmarosa oil (e.g., cymbopogonmartini); patchouli (e.g., pogostemon cablin); p-cymene; pennyroyal oil;pepper; peppermint (e.g., mentha piperita); perillaldehyde; petitgrain(e.g., citrus aurantium amara); phenyl ethyl alcohol; phenyl ethylpropionate; phenyl ethyl-2-methylbutyrate; pimento berry; pimento leaf;pinane hydroperoxide; pinanol; pine ester; pine needle; pine; pinene;piperonal; piperonyl acetate; piperonyl alcohol; plinol; plinyl acetate;pseudo ionone; rhodinol; rhodinyl acetate; rosalin; rose; rosemary(e.g., rosmarinus officinalis); ryu; sage; sandalwood (e.g., santalumalbum); sandenol; sassafras; sesame; soybean; spearmint; spice; spikelavender; spirantol; starflower; tangerine; tea seed; tea tree;terpenoid; terpineol; terpinolene; terpinyl acetate;tert-butylcyclohexyl acetate; tetrahydrolinalool; tetrahydrolinalylacetate; tetrahydromyrcenol; thulasi; thyme; thymol; tomato;trans-2-hexenol; trans-anethole and metabolites thereof; turmeric;turpentine; vanillin (e.g., 4-hydroxy-3-methoxy benzaldehyde); vetiver;vitalizair; white cedar; white grapefruit; (wintergreen) and the like.

In a further example embodiment, suitable essential oils or theirconstituents may include, but are not limited to, members selected fromthe group consisting of aldehyde C16 (pure), alpha-terpineol, amylcinnamic aldehyde, amyl salicylate, anisic aldehyde, benzyl alcohol,benzyl acetate, cinnamaldehyde, cinnamic alcohol, carvacrol, carveol,citral, citronellal, citronellol, dimethyl salicylate, eucalyptol(cineole), eugenol, iso-eugenol, galaxolide, geraniol, guaiacol, ionone,d-limonene, menthol, methyl anthranilate, methyl ionone, methylsalicylate, alpha-phellandrene, pennyroyal oil, perillaldehyde, 1- or 2phenyl ethyl alcohol, 1- or 2-phenyl ethyl propionate, piperonal,piperonyl acetate, piperonyl alcohol, D-pulegone, terpinen-4-ol,terpinyl acetate, 4-tert butylcyclohexyl acetate, thyme oil (white andred), thymol, trans-anethole, vanillin, ethyl vanillin, and the like.

In an example embodiment, each plant essential oil or derivativethereof, which may be extracted from natural sources or syntheticallymade, generally contains as a major constituent an acyclic monoterpenealcohol or aldehyde, a benzenoid aromatic compound containing at leastone oxygenated substituent or side chain, or a monocarbocyclic terpenegenerally having a six membered ring bearing one or more oxygenatedsubstituents.

As plant essential oil compounds are known and used for other uses, theymay be prepared by a skilled artisan by employing known methods. Forexample, the synthetic form of wintergreen oil (methyl salicylate) mayalso be used in the embodiment.

It will be appreciated by the skilled artisan that the pesticidalcompositions of the present invention unexpectedly exhibit excellentpesticidal activities using two or more U.S. Food and DrugAdministration approved plant essential oils, in lieu of conventionalpesticides which are not safe for use in households and other sensitiveareas, or in lieu of pesticidal compositions containing individual plantessential oils. It will also be appreciated by the skilled artisan thatthe pesticidal compositions of the present invention provide affordablepesticidal formulations that are aesthetically acceptable. It will alsobe appreciated by the skilled artisan that the pesticidal compositionsof the present invention unexpectedly exhibit excellent pesticidalactivities, specifically knockdown and mortality, using water-basedemulsions in both pressurized (e.g. an aerosol) and non-pressurizedsystems in lieu of oil based solvent systems.

Without wishing to be bound by the following theories, it is believedthat the plant essential oils attack a pest's nervous system or may actas Phase I and/or Phase II drug metabolizing enzyme inhibitors.Alternatively, pesticidal compositions of the present invention may actvia an alternative mode of action, as agonists or antagonists againstthe nerve receptor systems that are distinct to invertebrates, e.g., theoctopamine receptor system. As octopamine agonists, the pesticidalcompositions of the present invention act by binding to a receptor thatactivates adenylate cyclase which, in turn, produces secondary messengercyclic AMP. The cyclic AMP acts by binding to a cyclic AMP receptorgenerating hormonal-type activity. Pesticidal compositions of thepresent invention are highly active and are believed to have activitiesunexpectedly greater than octopamine. The term “octopamine agonist” ismeant to indicate a compound that mimics at least some of the effects ofoctopamine by interaction with the octopamine receptor. For example, anoctopamine agonist, like endogenous octopamine, may affect many areas ofinsect physiology, including carbohydrate metabolism, lipidmobilization, hematocyte function, heart rate, peripheral muscle tensionand excitability, and behavior. Thus, overactivation of the octopaminesystem in certain pests by an octopamine agonist may lead to behavioraland physiological abnormalities that have pestistatic and pesticidalconsequences. As octopamine agonists, the pesticidal compositions of thepresent invention act as highly selective pest control agents sincevertebrate species—as opposed to invertebrate, e.g., insect,species—lack octopamine receptors. As a result, any octopamine-receptorcontaining pest is treatable or controllable by the pesticidalcompositions of the present invention. These pests include allinvertebrate pests, including, but not limited to, round worms (e.g.,hookworm, trichina, ascaris); flatworms (e.g., liver flukes andtapeworms); jointed worms (e.g., leeches); molluscs (e.g., parasiticsnails); and arthropods (insects, spiders, centipedes, millipedes,crustaceans (e.g., barnacles)). In particular, included among thearthropods are ticks; mites (both plant and animal); lepidoptera(butterflies and moths and their larvae); hemiptera (bugs); homoptera(aphids, scales); and coleoptera (beetles). Also included are spiders;anoplura (lice); diptera (flies and mosquitoes); trichoptera; orthoptera(e.g., roaches); odonta; thysanura (e.g., silverfish); collembola (e.g.,fleas); dermaptera (earwigs); isoptera (termites); ephemerids(mayflies); plecoptera; mallophaga (biting lice); thysanoptera; andsiphonaptera (fleas); dictyoptera (roaches); psocoptera (e.g.,booklice); and certain hymenoptera (e.g., those whose larva feed onleaves). In another embodiment of the invention, there is provided amethod for controlling pests by treating said pests with an octopamineagonist of the invention in an amount effective to provide pest control,by either pesticidal or pestistatic activity.

In one aspect, the pesticidal compositions may use surfactants as partof the delivery or carrier system. The presence of nonionic, cationic oranionic surfactants, such as, sodium lauryl sulfate, nonylphenoxypolyoxyethylene and hydrogenated tallow dimethyl benzyl ammoniumchloride, can be used as adjuvants. Adjuvants are believed to confer thebroad spectrum pesticidal activity on the composition by acting as awetting, dispersing and/or emulsifying agent that facilitates or aids inthe spreading of the active rosemary and wintergreen oils across aninsect or larva, providing for a more uniform and rapid penetration ofthe oils through the exoskeleton (if present), thus permitting the oilsto exert their pesticidal activity on the internal organs and/or nervoussystem of the insect or larva. Non-limiting examples of anionicsurfactants such as salts of fatty acids, alkyl sulphates, alkyl ethersulphonates and alkyl aryl sulphonates. Other examples of preferredsurfactants include sodium dodecyl benzenesulfonic acid, alcoholethoxylate, olefin sulfonate, and modified phthalic glycerol alkydresins such as Latron B1956.

In another aspect, the plant essential oils of the present invention mayact as solvents against the waxy cuticle protecting invertebrate pests,thereby penetrating the cuticle and causing fast knockdown andmortality. The plant essential oils may penetrate the cuticle andcontact the nerve endings in the invertebrate pest's trachea, and causeneurotoxic activity. In any event, the net effect of the toxicity andaction of the inventive composition disclosed herein is heretoforeunknown and unexpected.

Use of pesticidal compositions of the present invention generallyresults in fast knockdown and 100% mortality on contact. As such, theyare advantageously employed as pesticidal agents in uses such as,without limitation, households, lawn and garden applications,agriculture, organic farming, greenhouse/nursery applications, storedproduct applications, professional pest control, pet bedding, foliageapplication, underwater or submerged application, solid treatment, soilincorporation application, seedling box treatment, stalk injection andplanting treatment, ornamentals, termites, mosquitoes, fire ants, headlice, dust mites, etc. Use of the pesticidal compositions of the presentinvention generally provides repellency to pests, and as such areadvantageously employed as plant protectants.

With respect to soil, the pesticidal compositions resist weatheringwhich includes wash-off caused by rain, decomposition by ultra-violetlight, oxidation, or hydrolysis in the presence of moisture or, at leastsuch decomposition, oxidation and hydrolysis as would materiallydecrease the desirable pesticidal characteristic of the pesticidalcompositions or impart undesirable characteristics to the pesticidalcompositions. The pesticidal compositions are so chemically inert thatthey are compatible with substantially any other constituents of pestcontrol, and they may be used in the soil, upon the seeds, or the rootsof plants without injuring either the seeds or roots of plants. They mayalso be used in combination with other pesticidally active compounds.

The term “carrier” as used herein means an inert or fluid material,which may be inorganic or organic and of synthetic or natural origin,with which the active compound is mixed or formulated to facilitate itsapplication to the container or carton or other object to be treated, orits storage, transport and/or handling. The pesticidal compositions ofthe instant invention also typically comprise an inert carrier, in anamount in which the inert carrier can assist the instant activeingredient to be carried through a process or method of controllingpests. As such an amount of the inert carrier, the inventive pesticidalcompositions preferably comprise the inert carrier in an amount of fromabout 5-99.9%, provided that such a carrier is a solid, liquid or gascarrier, or a combination thereof. In such a case, examples of the solidcarriers that may be in the pesticidal compositions of the instantinvention include clays such as kaolin, diatomaceous earth, bentonite,fubasami clay and terra alba, synthetic hydrated silicon oxides, talc,ceramics, other inorganic minerals which are useful in producingformulated compositions such as sericite, quartz, sulfur, active carbonsand calcium carbonate, chemical fertilizers such as ammonium sulfate,ammonium phosphate, ammonium nitrate, urea and ammonium chloride, andthe like, as well as powders thereof, granules thereof, and a mixturethereof; examples of the liquid carriers that may be in the pesticidalcompositions of the instant invention include water, alcohols such asmethanol and ethanol, aromatic hydrocarbons such as toluene, xylene,ethylbenzene and alkyl naphthalenes, non-aromatic hydrocarbons such ashexane, cyclohexane, kerosene, isoparoffinic and normal paroffinicsolvents and light oils, esters such as ethyl acetate and butyl acetate,nitrites such as acetonitrile and isobutylonitrile, ethers such asdiisopropyl ether and dioxane, amides such as N,N-dimethylformamide andN,N-dimethylacetamide, halogenated hydrocarbons such as dichloromethane,trichloroethane and carbon tetrachloride, dimethylsulfoxide, botanicaloils such as soy oil and cotton seed oil, and the like, and a mixturethereof; and examples of the gas carriers that may be in the aerosolform of pesticidal compositions of the instant invention includepropellants such as butane gas, propane gas, liquid petroleum gas,dimethyl ether, carbon dioxide, and the like, and a mixture thereof.

In general, any of the materials customarily employed in formulatingpesticides, (insecticides, miticides, herbicides, fungicides, etc.) aresuitable. The inventive pesticidal compositions of the present inventionmay be employed alone or in the form of mixtures with such solid and/orliquid dispersible carrier vehicles and/or other known compatible activeagents such as other insecticides, acaricides, nematicides, fungicides,bactericides, rodenticides, herbicides, fertilizers, growth-regulatingagents, etc., if desired, or in the form of particular dosagepreparations for specific application made therefrom, such as solutions,emulsions, suspensions, powders, pastes, and granules which are thusready for use. The pesticidal compositions of the present invention canbe formulated or mixed with, if desired, conventional inert pesticidediluents or extenders of the type usable in conventional pesticideformulations or compositions, e.g. conventional pesticide dispersiblecarrier vehicles such as gases, solutions, emulsions, suspensions,emulsifiable concentrates, spray powders, pastes, soluble powders,dusting agents, granules, foams, pastes, tablets, aerosols, natural andsynthetic materials impregnated with active compounds, microcapsules,coating compositions for use on seeds, and formulations used withburning equipment, such as fumigating cartridges, fumigating cans andfumigating coils, as well as ULV cold mist and warm mist formulations,etc. In addition, mineral oil and the essential oils disclosed herein(e.g., safflower oil, benzyl alcohol, citronellal, d-limonene, soybeanoil, sesame oil, etc.) may also serve as diluents or carriers in thepesticidal compositions of the present invention.

Formulations containing the pesticidal compositions of the presentinvention may be prepared in any known manner, for instance by extendingthe pesticidal compositions with conventional liquid carriers and/ordispersible solid carriers optionally with the use of carrier vehicleassistants, e.g. conventional pesticide surface-active agents, includingemulsifying agents and/or dispersing agents, whereby, for example, inthe case where water is used as diluent, organic solvents may be addedas auxiliary solvents. Suitable liquid diluents or carriers includewater, petroleum distillates, or other liquid carriers with or withoutsurface active agents. The choice of dispersing and emulsifying agentsand the amount employed is dictated by the nature of the composition andthe ability of the agent to facilitate the dispersion of the pesticidalcompositions of the present invention. Non-ionic, anionic, amphoteric,or cationic dispersing and emulsifying agents may be employed, forexample, the condensation products of alkylene oxides with phenol andorganic acids, alkyl aryl sulfonates, complex ether alcohols,quarternary ammonium compounds, and the like.

Liquid concentrates may be prepared by dissolving a composition of thepresent invention with a solvent and dispersing the pesticidalcompositions of the present inventions in water with suitable surfaceactive emulsifying and dispersing agents. Examples of conventionalcarrier vehicles for this purpose include, but are not limited to,aerosol organic solvents, such as aromatic hydrocarbons (e.g. benzene,toluene, xylene, alkyl naphthalenes, etc.), halogenated especiallychlorinated, aromatic hydrocarbons (e.g. chloro-benzenes, etc.),cycloalkanes, (e.g. cyclohexane, etc.). paraffins (e.g. petroleum ormineral oil fractions), chlorinated aliphatic hydrocarbons (e.g.methylene chloride, chloroethylenes, etc.), alcohols (e.g. methanol,ethanol, propanol, butanol, glycol, etc.) as well as ethers and estersthereof (e.g. glycol monomethyl ether, etc.), amines (e.g. ethanolamine,etc.), amides (e.g. dimethyl formamide etc.) sulfoxides (e.g. dimethylsulfoxide, etc.), acetonitrile, ketones (e.g. acetone, methyl ethylketone, methyl isobutyl ketone, cyclohexanone, etc.), and water.

Surface-active agents, i.e., conventional carrier vehicle assistants,that may be employed with the present invention include, withoutlimitation, emulsifying agents, such as non-ionic and/or anionicemulsifying agents (e.g. polyethylene oxide esters of fatty acids,polyethylene oxide ethers of fatty alcohols, alkyl sulfates, alkylsulfonates, aryl sulfonates, albumin hydrolyzates, etc. and especiallyalkyl arylpolyglycol ethers. In the preparation of wettable powders,dust or granulated formulations, the active ingredient is dispersed inand on an appropriately divided carrier. In the formulation of thewettable powders the aforementioned dispersing agents as well aslignosulfonates can be included. Dusts are admixtures of thecompositions with finely divided solids such as talc, attapulgite clay,kieselguhr, pyrophyllite, chalk, diatomaceous earth, vermiculite,calcium phosphates, calcium and magnesium carbonates, sulfur, flours,and other organic and inorganic solids which act as carriers for thepesticide. These finely divided solids preferably have an averageparticle size of less than about 5 microns. A typical dust formulationuseful for controlling insects contains 5 parts of pesticidalcomposition and 95 parts of diatomaceous earth or vermiculite. Granulesmay comprise porous or nonporous particles. The granule particles arerelatively large, a diameter of about 400-2500 microns typically. Theparticles are either impregnated or coated with the inventive pesticidalcompositions from solution. Granules generally contain 0.05-25%,preferably 0.5-15%, active ingredient as the pesticidally-effectiveamount. Thus, the contemplated are formulations with solid carriers ordiluents such as bentonite, fullers earth, ground natural minerals, suchas kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite ordiatomaceous earth, vermiculite, and ground synthetic minerals, such ashighly-dispersed silicic acid, alumina and silicates, crushed andfractionated natural rocks such as calcite, marble, pumice, sepioliteand dolomite, as well as synthetic granules of inorganic and organicmeals, and granules of organic materials such as sawdust, peanuts, applepomace, recycled paper, coconut shells, corn cobs and tobacco stalks.Adhesives, such as carboxymethyl cellulose, natural and syntheticpolymers, (such as gum arabic, polyvinyl alcohol and polyvinyl acetate),and the like, may also be used in the formulations in the form ofpowders, granules or emulsifiable concentrations.

Further, the pesticidal compositions of the instant invention mayadditionally contain a coloring agent, a formulation auxiliary, or acombination thereof. As such, examples of such coloring agents that maybe utilized in the pesticidal compositions of the instant inventioninclude inorganic pigments such as metal oxides, titanium oxides andPrussian blue, organic dyes such as alizarine dyes, azo dyes andmetallic phthalocyanine dyes, iron, manganese, boron, copper, cobalt,molybdenum, zinc and salts thereof, and the like, or a mixture thereof;and examples of such formulation auxiliaries that may be utilized in thepesticidal compositions of the instant invention include attachingand/or dispersing agents, surfactants, stabilizers, and the like, or amixture thereof.

If desired, colorants such as inorganic pigments, for example, ironoxide, titanium oxide and Prussian Blue, and organic dyestuffs, such asalizarin dyestuffs, azo dyestuffs or metal phthalocyanine dyestuffs, andtrace elements, such as salts of iron, manganese, boron, copper, cobalt,molybdenum and zinc may be used.

In commercial applications, the present invention encompasses carriercomposition mixtures in which the pesticidal compositions are present inan amount substantially between about 0.01-100% by weight, andpreferably 0.5-90% by weight, of the mixture, whereas carriercomposition mixtures suitable for direct application or fieldapplication generally contemplate those in which the active compound ispresent in an amount substantially between about 0.0001-10%, preferably0.01-2%, by weight of the mixture. Thus, the present inventioncontemplates over-all formulations that comprise mixtures of aconventional dispersible carrier vehicle such as (1) a dispersible inertfinely divided carrier solid, and/or (2) a dispersible carrier liquidsuch as an inert organic solvent and/or water, preferably including asurface-active effective amount of a carrier vehicle assistant, e.g. asurface-active agent, such as an emulsifying agent and/or a dispersingagent, and an amount of the active compound which is effective for thepurpose in question and which is generally between about 0.0001-100%,and preferably 0.01-95%, by weight of the mixture.

The pesticidal compositions can also be used in accordance withso-called ultra-low-volume process, i.e. by applying such compounds orby applying a liquid composition containing the same, via very effectiveatomizing equipment, in finely divided form, e.g. average particlediameter of from 50-100 microns, or even less, i.e. mist form, forexample by airplane crop spraying techniques. In this process it ispossible to use highly concentrated liquid compositions with said liquidcarrier vehicles containing from about 20 to 95% by weight of thepesticidal compositions or even the 100% active substances alone, e.g.about 20-100% by weight of the pesticidal compositions. Theconcentration in the liquid concentrate will usually vary from about 10to 95 percent by weight. Furthermore, the present invention encompassesmethods for killing, combating or controlling invertebrate pests, whichcomprises applying to at least one of correspondingly (a) suchinvertebrate pests and (b) the corresponding habitat thereof, i.e. thelocus to be protected, e.g. to the household, a correspondinglycombative, a pesticidally effective amount, or toxic amount of theparticular pesticidal compositions of the invention alone or togetherwith a carrier as noted above. The instant formulations or compositionsmay be applied in any suitable usual manner, for instance by spraying,atomizing, vaporizing, scattering, dusting, watering, squirting,sprinkling, pouring, fumigating, and the like. The method forcontrolling invertebrate pests such as cockroaches and ants comprisesapplying the inventive composition, ordinarily in a formulation of oneof the aforementioned types, to a locus or area to be protected from thecockroaches and/or ants, such as the household. The compound, of course,is applied in an amount sufficient to effect the desired action. Thisdosage is dependent upon many factors, including the targeted pest, thecarrier employed, the method and conditions of the application, whetherthe formulation is present at the locus in the form of an aerosol, or asa film, or as discrete particles, the thickness of film or size ofparticles, and the like. Proper consideration and resolution of thesefactors to provide the necessary dosage of the active compound at thelocus to be protected are within the skill of those versed in the art.In general, however, the effective dosage of the compound of thisinvention at the locus to be protected, i.e., the dosage with which thepest comes in contact-is of the order of about 0.001 to about 5.0% basedon the total weight of the formulation, though under some circumstancesthe effective concentration will be as little as 0.0001% or as much as20%, on the same basis.

The pesticidal compositions and methods of the present invention areeffective in the control of different species of invertebrate pests andit will be understood that the pests exemplified and evaluated in theworking Examples herein is representative of such a wider variety. Byway of example, but not limitation, the pesticidal compositions of thepresent invention are also useful for control of pests such as fleas,mosquitoes, bees such as yellow jackets and wasps, cockroaches includingthe American and German cockroach, termites, houseflies and silverleafwhiteflies (Bemisia argentifolii), leaf hoppers such as the grape orpotato leafhoppers (Cicidellidae), cabbage looper (Lepidoptera), antssuch as the pharaoh ant, argentine ant, carpenter ant and fire ant,stink or lygus bugs, leafminers (Liriomyza trifollii), western flowerthrips (Frankliniella occidentalis) and sucking or chewing insects suchas thrips and aphids such as melon aphids (Aphis gossypii), black beanaphids (Aphis fabae); arachnids such as spiders, ticks and plant mites,including two-spotted spider mites (Tetronmychua urticae), McDanielmites, Pacific mites and European mites; gastropods such as slugs andsnails; fungi such as powdery mildew including cladosporium, strawberrypowdery mildew, rusts, botrytis, ergots, blight, downy mildew, eutypa,leaf spot, smut, Chytridimycota, Zygomycota, Asomycota, ringworm,rhizopus, rhizoctonia, pythium and erwinia; nematodes; and bacteria.Further targeted pests controlled by the pesticidal composition of thepresent invention are, for example, the pillbugs and Isopoda (sowbugs)such as Oniscus asellus, Armadillidium vulgare (Latreille pillbug) andPorcellio scarber, Pieris rapae crucivora (common cabbageworm),Spodoptera litura (tobaccocutworm), Thrips palmi (melon thrips),Empoasca onukii (tea green leafhopper), Phyllonorycter ringoniella(appleleafminer), Lissorhoptrus oryzophilus (rice water weevil),Popillia japonica (Japanese beetle), Phyllotreta (striped flea beetle),Tetranychus kanzawai (Kanzawa spidermite), Polyphagotarsonemus latus(broad mite); Diplopoda such as Blanilus guttulatus (millepede);Chilopoda such as Geophilus carpophagus, Scutigera spp., Scolopendrasubspini and Thereunema spp.; Symphyla such as Scutigerella immaculata;Thysanura (bristletails) such as Ctenolepisma villosa (orientalsilverfish) and Lepisma saccharina (silverfish); Psocoptera such asTrogium pulsatorium (larger pale booklice); Collembola (snowfleas) suchas Onichiurus armatus; Isoptera (termites) such as Mastotermitidae,Termopsidae (e.g. Zootermopsis, Archotermopsis, Hodotermopsis,Porotemes), Kalotermitidae (e.g. Kalotermes, Neotermes, Cryptotermes,Incisitermes, Glyptotermes), Hodotermitidae (e.g. Hodotermes,Microhodotermes, Anacanthotermes), Rhinotermitidae (e.g. Reticulitermes,Heterotermes, Coptotermes, Schedolinotermes), Serritermitidae andTermitidae (e.g. Anitermes, Drepanotermes, Hopitalitermes,Trinervitermes, Macrotermes, Odontotermes, Microtermes, Nasutitermes,Pericapritermes, Anoplotermes); Dictyoptera (cockroaches) such as Blattaorientalis (oriental cockroach), Periplaneta americana (Americancockroach), Periplaneta fuliginosa (smokybrown cockroach), Leucophaeamaderae and Blattella germanica (German cockroach); Orthoptera such asGryllotapa spp. (mole cricket), Acheta domesticus, Teleogryllus emma(field cricket), Locusta migratoria (asiatic locust/oriental migratorylocust), Melanoplus differentialis and Schistocera gregaria; Dermaptera(earwigs) such as Labidura riparia and Forficula auricularia; Anoplurasuch as Phthirus pubis, Pediculus humanus, Haematopinus sulus,Linognathus spp. and Solenopotes spp.; Mallophaga such as Trichodectesspp., Tromenopon spp., Bovicola spp. and Felicola spp.; Thysanoptera(thrips) such as Frankiniella intonsa (flower thrips), onion thrips,Thrips tabaci (cotton seedling thrips) and Thrips palmi; Heteropterasuch as Nezara spp., Eurygaster spp., Dysdercus intermedius, Cimexlectularis, Triatoma spp., Rhodnius prolixus, Nezara antennata (greenstink bug) and Cletus puncttiger; Homoptera such as Aleurocanthusspiniferus (citrus spiny whitefly), Bemisia tabaci (sweetpotatowhitefly), Trialeurodes vaporariorum (greenhouse whitefly), cottonasphid, Aphis gossypii (melon aphid), Brevicoryne brassicae (cabbageasphid), Cryptomyzus ribis, Aphis fabae, Macrosiphum euphorbiae (potatoaphid), Myzus persicae (green peach aphid), Phorodon humuli, Empoascaspp., Nephootettix cincticeps (green rice leafhopper), Lecanium corni(brown scale), Saissetia oleae (black scale), Laodelphax striatellus(small brown plant hopper), Nilaparvata lugens (brown rice planthopper),Aonidiella aurantii (red scale), Aspidiotus hederae (ivy scale),Pseudococcus spp., Psylla spp. and Phylloxera vastrix; Lepidoptera suchas Pectinophora gossypiella (pink bollworm), Lithocolletis blancardella,Plutella xyloste (diamondback moth), Malacosoma neustria (tentcatapillar), Euproctis subflava (oriental tussock moth), Lymantriadispar (gypsy moth), Bucculatrix pyrivorella (pear leafminer),Phyllocnistis citrella (citrus leafminer), Agrotis spp., Euxoa spp.,Earias insulana, Heliothis spp., Spodoptera exigua (beet armyworm),Spodoptera litura (common cutworm), Spodoptera spp., Mamestra brassicae(cabbage armyworm), Trichoplusia ni, Carpocapsa pomonella, Pieris spp.,Chilo spp., Pyrausta nubilalis, Ephestia kuehniella (Mediterranean flourmoth), Galleria mellonella (greater wax moth), Tineola bisselliella(webbing clothes moth), Tenea translucens, oriental tea tortrix (Homonamagnanima) and Totrix viridana; Coleoptera (beetles) such as Anobiumpunctatum, Rhizopertha dominica (lesser grain borer), Acanthoscelidesobectus (bean weevil), Agelastica alni, Leptinotarsa decemlineata,Phaedon cochleariae, Diabrotica spp., Psylliodes angusticollis (solanumflea beetle), Phyllotreta striolata (striped flea beetle), Epilachnaspp., Atomaria spp., Oryzaephilus surinamensis (sawtoothed grainbeetle), Anthonomus spp., sitophilus spp., Otriorhynchus sulcatus (blackvine weevil), Cosmopolites sordidus (banana weevil borer),Ceuthorhyncidius albosuturalis, Hypera postica (alfalfa weevil),Dermestes spp., Trogoderma spp., Attagenus unicolor (black carpetbeetle), Lyctus spp., Meligethes aeneus, Ptinus spp., Gibbiumpsylloides, Tribolium spp., Tenebrio molitor (yellow mealworm), Agriotesspp., Melolontha mololontha, Scolytidae (e.g. Xyleborus andScolytoplatypus), Cerambycidae (e.g. Monochamus, Hylotrupes,Hesperophanus, Chlorophorus, Palaeocallidium, Semanotus, Purpuricenus,Stromatium), Platypodidae (e.g. Crossotarsus, Platypus), Bostrychidae(e.g. Dinoderus, Bostrychus, Sinoderus), Anobiidae (e.g. Ernobius,Anobium, Xyletinus, Xestobium, Ptilinus, Nicobium, Ptilneurus) andBuprestidae; Hymenoptera such as Diprion spp., Hoplocampa spp., Lasiusspp., Formica japonica, Vespa spp., and Siricidae (e.g. Urocerus,Sirex); Diptera such as Aedes spp., Anopheles spp., Culex spp.,Drosophila melanogaster, Musca domestica (housefly), Fannia spp.,Calliphora spp., Lucilia spp., Chrysomya spp., Cuterebra spp.,Gastrophilus spp., Stomoxys spp., Oestrus spp., Hypoderma spp., Tabanusspp., Bibio hortulanus, Pegomyia hyoscyami, Ceratitus capitata, Dacusdorsalis (oriental fruit fly), Tipula paludosa, Simulium spp.,Eusimulium spp., Phlebotomus spp., Culicoides spp., Chrysops spp.,Haematopota spp., Braula spp., Morellia spp., Glossina spp., Wohlfahrtiaspp., Sarcophaga spp., Lipoptena spp., Melophagus spp. and Muscina spp.;Siphonaptera such as Xenopsylla cheopis, Ceratophyllus spp., Pulex spp.(human flea) and Ctenocephalides spp. (cat flea/dog flea); Arachnidasuch as Scorpio maurus, Latrodectus mactans and Chiracanthium spp.;mites such as Otodectus spp., Acarus siro (grain mite), Argas spp.,Ornithodoros spp., Ornithonyssus spp., Dermanyssus spp., Eriophyes spp.,Chelacaropsis moorei, Dermatophagoides spp., Psoroptes equi, Chorioptesspp., Saracoptes spp., Tarsonemus spp., clover mite (Bryobia praetiosa),Panonychus spp., Tetranychus spp. (spider mites), Raillietas spp.,Pneumonyssus spp., Sternostorma spp., Acarapis spp., Cheyletiella spp.,Myobia spp., Psorergates spp., Demodex spp., Trombicula spp.,Listrophorus spp., Tyrophagus spp., Sarcoptes spp., Notoedres spp.,Cytodides spp., Laminosioptes spp.; and the like.

While the composition of the present invention has the excellentpesticidal activities against various species of pests, it showsparticularly favorable efficacy for control of vector or nuisance pestsincluding cockroaches such as German cockroach (Blattella germanica),smokybrown cockroach (Periplaneta fuliqinosa), American cockroach(Periplaneta americana), brown cockroach (Periplaneta brunnea) andoriental cockroach (Blatta orientalis), house mites such as mold mite(Tyrophagus putrescentiae), American house dust mite (Dermatophagoidesfarinae) and Cheyletid mites (Chelacaropsis), fleas such as cat flea(Ctenocephalides felis), mosquitos such as brown house mosquito (Culexpipiens pallens) and Asian tiger mosquito (Aedes albopictus), and fliessuch as housefly (Musca domestica), and wood pests including termitessuch as Formosan substerranean termite (Copptotermes formosanus),Japanese subterranean termite (Reticulitermes speratus), American commondry-wood termite (Incistermes minor), Daikoku dry-wood termite(Cryptotermes domesticus), Odontotermes formosanus, Coptotermesformosanus, Reticulitermes speratus, R. flavipes, R. hesperus, R.virqinicus, R. tibialis, Incisitermes minor, Cryptotermes domesticus,Odontotermes formosanus, and Heterotermes aureus, termite species of thefamilies (and pest genera) Mastotermitidae (Mastotermes species),Hodotermididae (Anacanthotermes, Zootermopsis species), Rhinotermitidae(Coptotermes, Heterotermes, Reticulitermes, Psammotermes,Prorhinotermes, Schedorhinotermes species), Kalotermitidae(Glyoptotermes, Neotermes, Cryptotermes, Incisitermes, Kalotermes,Marqinitermes species), Serritermitidae, and Termitidae(Pericapritermes, Allodontermes, Microtermes, Odontotermes,Nasutitermes, Termes, Amitermes, Globitermes, Microcerotermes species),Termopsidae (Hodotermopsis, Zootermopsis species), and other pestspecies of termites, raw logvermin such as bark beetles (Scolytidae),longicorn beetles (Cerambycidae), weevils (Curculionidae), pinholeborers (Platypodidae) and horntails (Siricidae), and dry wood verminsuch as powderpost beetle (Lyctus brunneus), false powderpost beetles(Bostrychidae), deathwatch and drugstore beetles (Anobiidae) anddry-wooden longicorn bettle (Stromatium longicorne).

An exemplary method for controlling pests comprises applying (such as byspraying) to a pest or site of pest infestation, a pesticidallyeffective amount of a pesticidal composition of the present invention inan amount sufficient to prevent infestation of the host and thecomposition does not damage the host's tissue. Of particular interest isuse of the pesticide compositions of the invention in treating fungalinfestations of fruit bearing plants such as strawberry plants. Bytreatment of a diseased plant with the composition of the invention inan amount sufficient to treat such a fungal infestation, pests such aspowdery mildew can be controlled or eliminated, thus restoring the plantto a healthy state. Also of particular interest is use of the pesticidecompositions of the invention in controlling arthropod infestations ofornamental plants such as roses. By treatment of a diseased plant withthe composition of the invention in an amount sufficient to treat such aarthropod infestation, pests such as aphids and spider mites can becontrolled or eliminated, thus restoring the plant to a healthy state.

Use of pesticides is regulated in the United States by the EnvironmentalProtection Agency (EPA) under authority of the Federal Insecticide,Fungicide and Rodenticide Act (FIFRA). Tolerance for residues ofpesticides in agricultural commodities are established by the (EPA) andenforced by the Food and Drug Administration (FDA) under authority ofthe Federal Food, Drug and Cosmetic Act (FD&C Act). This regulatoryenvironment leads to another aspect of this invention, which is anarticle of manufacture. In this aspect a pesticidally active compositionof the present invention is sold in a container that will be suitablefor storing the composition for its shelf life. Associated with thecontainer is printed instructions and/or a printed label indicating thatthe subject composition can be used to control pests, i.e., used as apesticide and providing instructions for using the composition forpesticidal purposes in accordance with the treatment method set forthherein. The container may have associated with it a delivery device thatallows the composition to be applied to the pest population or to thearea to be treated. For liquid compositions this is generally ahand-operated, motorized or pressurized pressure-driven sprayer. Thecontainer may be made of any suitable material such as a polymer, glass,metal, or the like. Usually, the labeling is associated with thecontainer by being adhered to the container, or accompanying thecontainer in a package sold to the user. Such label may indicate thatthe composition is approved for use as a pesticide. The instructionswill spell out the type of pests for which the pesticidal composition isto be used, the application method, the rate of application, dilutionrequirements, use precautions, and the like.

The efficacy of the pesticidal compositions of the present invention maybe monitored by determining the mortality of or damage to the pestpopulation, i.e., by determining its adverse effect upon treated pests.This includes damage to the pests, inhibition or modulation of pestgrowth, inhibition of pest reproduction by slowing or arresting itsproliferation, or complete destruction/death of the pest, all of whichare encompassed by the term “controlling”. The term “pesticidallyeffective amount” is an amount of the compound of the invention, or acomposition containing the compound, that has an adverse affect on atleast 25% of the pests treated, more preferably at least 50%, mostpreferably at least 70% or greater. Preferably, an “effectivepest-inhibiting amount” is an amount of the compound of the invention,or a composition containing the compound, where 25% or greater mortalityagainst pests is achieved, preferably 50% or greater, more preferably70% or greater mortality. Similarly, an “effective pest-growthmodulating amount” is preferably one where 25% or greater pest-growthmodulation is achieved, preferably 50% or greater, more preferably 70%of greater. The term “amount sufficient to prevent infestation” is alsoused herein and is intended to mean an amount that is sufficient todeter all but an insignificant sized pest population so that a diseaseor infected state is prevented. The actual value of a pesticidallyeffective amount for a given compound is preferably determined byroutine screening procedures employed to evaluate pesticidal activityand efficacy, such as are well known by those skilled in the art and asare described in the Examples. It is expected that compounds of theinvention having a higher level of pesticidal activity can be used insmaller amounts and concentrations, while those having a lower level ofactivity may require larger amounts or concentrations in order toachieve the same pesticidal effect. Efficacy is also monitored byphytotoxicity to the plants that are infested with the pest population,tissue damage to the host infected with the pest population and anyadverse effects that might be experienced by a human user who isapplying the composition to an infested plant or animal. Accordingly,the amount of composition or active compound used in the methods of theinvention, meets the mortality, modulation or prevention criteria above,and preferably has minimal or no adverse effect on ornamental andagricultural plants (such as phytotoxicity), wildlife and humans thatmay come into contact with such compound.

The composition and method of the present invention will be furtherillustrated in the following, non-limiting Examples. The Examples areillustrative of various embodiments only and do not limit the claimedinvention regarding the materials, conditions, weight ratios, processparameters and the like recited herein.

EXAMPLE 1 Pesticidal Effects of Rosemary Oil and Wintergreen Oil

Studies were conducted to evaluate the individual toxicity, in terms ofspeed of action and mortality, of rosemary oil and wintergreen oilagainst American cockroaches, and then a blend of these two oils todetermine if similar toxic effects could be obtained using a proprietaryblend that was less expensive to produce and easier to employ indifferent end-use formulations. Methyl salicylate was used aswintergreen oil. American cockroaches were confined under a screened capand then sprayed with approximately 3.7 grams of each test chemicalusing a trigger sprayer. Immediately after spraying, the insects werereleased into a large plastic container and observed for signs oftoxicity. Three American cockroaches were used in each experiment. Thetimes for immobilization (IM), knockdown (KD), and mortality wererecorded for each test insect. An untreated control was provided. Nomortality was observed in the control.

IM KD Mortality 100% Methyl Salicylate — 31 sec >2 min — 1 m 35 sec >2min 45 sec — >2 min 100% Rosemary Oil — 10 sec 1 m 15 sec — 10 sec 1 m46 sec — 48 sec >2 min 80% Methyl Salicylate — 10 sec 1 m 05 sec 20%Rosemary Oil — 20 sec 1 m 23 sec —  8 sec 40 sec 

The above data demonstrates the fast action of rosemary oil in terms ofboth knockdown and mortality as compared to wintergreen oil. The studyfurther demonstrates that a proprietary blend of rosemary oil withwintergreen oil will perform as well or better than rosemary oil byitself. The ratio of wintergreen oil to rosemary oil in this blend is4:1.

EXAMPLE 2 Pesticidal Effects of Rosemary Oil and Wintegreen Oil withMineral Oil Against Plant Pests

A formulation (DR-A-034) consisting of 5% w/w rosemary oil, 22.5% w/wwintergreen oil, 22.5% w/w mineral oil, 0.5% w/w lecithin (emulsifier),and 49.5% w/w water was prepared and labeled Hexacide™. Hexacide™ wasapplied in dilute form at different rates per acre to the pests itemizedbelow in various greenhouse and field studies. In all of these studies,positive controls consisting of conventional pesticides were utilizedfor comparative efficacy. In laboratory and greenhouse tests, thefollowing exemplary pests were successfully controlled with HEXACIDE™.

Common Name Scientific Name Boll Weevil Anthonomus grandis ColoradoPotato Beetle Leptinotarsa decemlineata Green Peach Aphid Myzus persicaePotato Aphid Macrosiphum euphorbiae Strawberry Aphid Chaetosiphosfragaefolii Western Flower Thrips Frankinelli occidentalis Two SpottedSpidermite Tetranychus urticae Beet Armyworm Spodoptera exiguaBlackheaded Fireworm Rhopobota naevana Cabbage Looper Tricholplusea niCodling Moth Cydia pomonella Diamondback Moth Plutella xylostella FallArmyworm Spodoptera frugipetda Oblique-Banded Leafroller Choristoneurarosaceana Silverleaf Whitefly Bemisia argentifolii Sweetpotato WeevilCylas fromicarius elegantulus Tomato Pinworm Keiferia lycoperscellaTomato Fruitworm Helicoverpa zea Yellowstriped Armyworm SpodopteraornithogalliEfficacy

In greenhouse and field studies, HEXACIDE™ (DR-A-034) providedequivalent results to commercialy available chemical pesticide such asTalstar®, Avid®, Agri-Mek®, Kelthane®, Capture®, and Conserve®, (seeTables 1-11 and FIGS. 1-11). Table 1 below shows the effectiveness ofHEXACIDE™ Against Green Peach Aphid Myzus persicae on Ornamental SweetPotato Lpomora batatas.

TABLE 1 Number of Live Motiles Rate/ Pre- 1 % Treatment 100 galtreatment DAT 2 DAT 7 DAT Control Untreated / 36 a 34 a 61 a 67 a /Control HEXACIDE ™  64 oz 45 a  3 b  0 b  0 c 100 HEXACIDE ™ 128 oz 66 a 2 b  0 b  1 c 98.5 HEXACIDE ™ 256 oz 39 a  0 b  0 b  0 c 100 Talstar ® 10 oz 41 a 10 b  9 b 29 b 58.2 LSD (P = 0.05) 52.4  8.3 16.9 18.3 SD31.4  4.9 10.1 11Means followed by same letter do not significantly differ (p=0.05,Duncan's New MRT)

-   DAT: days after treatment-   Latron B-1956 at 0.0625% v/v used as adjuvant-   Three replicates per treatment

Table 2 below shows the effectiveness of HEXACIDE™ against the GreenPeach Aphid (Myzus persicae) on Cotton.

TABLE 2 Means followed by same letter do not significantly differ (p =0.05, Duncan's New MRT) DAT = days after treatment Latron B-956 at0.0625% v/v used as adjuvant Three replicates per treatment. 125 GPANumber of Live Number of Live Nymphs % Control Adults % Control(Pretreatment (Pretreatment Rate 1 DAT 2 DAT) 1 DAT 2 DAT) UntreatedControl 0 32.0 a 25.3 a 42.3 a 26.8 a 47.5 a 27.0 a HEXACIDE ™ 256 oz37.0 a 31.3 a  0.8 a  3.5 b  3.0 b  7.8 b 93.6 71.1 Talstar ®  10 oz44.3 a 33.0 a 25.5 a 12.3 ab  6.0 b 10.8 b 87.4 61.8 LSD (p = 0.05) 38.523.7 46.3 16.6 33.3 12.2 SD  6.2 14.8 28.9 10.4 20.8  7.6

Table 3 below exemplifies the effectiveness of HEXACIDE™ against thestrawberry aphid Chaetosiphos fragaefoliion on Strawberries. Meansfollowed by same letter does not significantly differ (p=0.05 Duncan'sNew MRT). A randomized complete block design was used. 35 gallons peracre spray volume (GPA) was employed. DAT=Days After Treatment

Four Replicates per treatment were performed.

TABLE 3 Number of Live Aphids Rate/ Pre- % Treatment Acre treatment 3DAT 7 DAT 14 DAT Control Untreated / 17.4 a 16.9 a  13.3 a  21.0 a  /Control HEXACIDE ™ 1 qt 17.4 a 3.3 b 1.2 b 0.7 b 96.6 HEXACIDE ™ 2 qt18.1 a 2.7 b 1.2 b 0.5 b 97.6 HEXACIDE ™ 4 qt 15.5 a 2.8 b 1.1 b 0.7 b96.7 Capture ® 4 oz 16.2 a 2.5 b 0.8 b 0.2 b 99.0

Table 4 below exemplifies the effectiveness of HEXACIDE™ AgainstGreenhouse Whitefly Trialurodes vaporariorum on Poinsetta Euphorbiapuicherrima. Means followed by same letter does not significantly differ(p=0.05 Duncan's New MRT). Results recorded 7 days after the secondtreatment. Latron B-1956 @ 0.0625% was used as an adjuvant. Eightreplicates per treatment were performed.

TABLE 4 Rate/ Number of Live Insects (% Control) Treatment 100 galNymphs Pupae Eggs Untreated Control / 230.1  10.3  183.4  HEXACIDE ™ 32oz 48.5 (78.9%) 5.1 (50.4%) 71.6 (60.9%) HEXACIDE ™ 128 oz  40.3 (82.5%)2.5 (75.7%) 57.0 (63.5%) Agri-Mek ® 30 oz 68.8 (70.1%) 5.9 (42.7%) 118.6(35.3%)  LSD (p = 0.05) 42.56 13.91 31.84 SD 41.56 13.58 31.09

Table 5 below shows the effectiveness of HEXACIDE™ Against WesternFlower Thrip Frankliniella occidentalis on Marigold Tagetes erecta.Means followed by same letter do not significantly differ (p=0.05,Duncan's New MRT). DAT=days after treatment. Latron B-1956 at 0.0625%v/v used as an adjuvant. Three replicates per treatment were performed.

TABLE 5 Rate/ Number of Live Motiles Treatment 100 gal. Pretreatment 1DAT 3 DAT Untreated Control /  8 a 39 a 17 a HEXACIDE ™ 128 oz 11 a  0 d 8 b Conserve ® 6 fl oz 12 a 22 b  1 c LSD (p = 0.05) 10.5 11.2  7.8 SD 6.2  6.7  4.7

Table 6 below shows the effectiveness of HEXACIDE™ Against Two-SpottedSpider Mite Tetranychus urticae on bell peppers. Means followed by sameletter do not significantly differ (p=0.05, Duncan's New MRT). Fourreplicates per treatment were performed.

TABLE 6 Number of Live Mites Rate/ Pre- 15 % Treatment 100 gal treatment5 DAT 10 DAT DAT Control Untreated / 62.0 a 36.7 cc 30.7 c 9.8 b /Control HEXACIDE ™ 120 oz  55.7 a  1.8 a  0.5 a 1.0 a 89.7 HEXACIDE ™ 60oz 65.8 a  4.3 a  0.7 a 1.2 a 87.7 Avid ®   4 oz. 62.2 a  7.2 ab  1.3 ab0.5 a 94.8 Tetrasan SWD 16 oz 59.5 a 14.3 cd  4.3 b 0.3 a 96.9

Table 7 below shows the effectiveness of HEXACIDE™ Against Two-SpottedSpider Mite Tetranychus urticae on Marigold Tageies eroota. Meansfollowed by same letter do not significantly differ (p=0.05, Duncan'sNew MRT). DAT=days after treatment. Latron B-1956 at 0.065% v/v used asan adjuvant. Three replicates per treatment were performed.

TABLE 7 Rate/ Number of Live Motiles 100 Pre- % Treatment gal treatment1 DAT 3 DAT 7 DAT Control Untreated /  91.7 a 165 a 355 a 370 a /Control HEXACIDE ™ 16 oz 144.3 a  55 b  89 b  63 cd 81.6 HEXACIDE ™ 32oz  87 a  43.7 b  96.7 b  97 cd 73.6 HEXACIDE ™ 64 oz  59.3 a  21.3 b 32 b  60 d 83.7 Avid ®  2 oz 110.6 a  52 b  77.7 b  24.3 d 93.4 LSD (P= 0.05) 127.2  53.9 124.6  92.6 SD  75.7  32.1  74.2  55.1

Table 8 below shows the effectiveness of HEXACIDE™ Against Two-SpottedSpider Mite Tetranychus urticae on Strawberries. Field Trials. Meansfollowed by same letter does not significantly differ (p=0.05 Duncan'sNew MRT). Four replicates per treatment were performed.

TABLE 8 Number of Live Mites Rate/ Pre- % Treatment acre treatment 3 DAT7 DAT 14 DAT Control Untreated / 24.3 ab 47.3 a 19.8 a 17.5 a / ControlHEXACIDE ™ 1 qt 17 b 31.3 bc  5.3 b  6.3 b 64 HEXACIDE ™ 2 qt 31.8 b 28bc  1.5 b  1.8 c 89.7 HEXACIDE ™ 4 qt 35.5 ab 28 bc  5.3 b  1.5 c 91.4Agri-Mek ® 8 oz. 24.3 ab 35 b  2.3 b  5.8 bc 66.8 LSD (p = 0.05) 14.111.4  4.6  2.7 SD  9.59  7.7  3.2  1.8

Table 9 below shows the effectiveness of HEXACIDE™ Against Two-SpottedSpider Mite Tetranychus urticae on Strawberry. A randomized completeblock design was utilized. Four replicates per treatment (200 gallonsspray volume per acre (GPA).) were performed utilizing.

TABLE 9 Number of Live Motiles Pre- Rate/ treatment Treatment Acre 6/86/15 6/22 6/29 7/5 7/12 Untreated / 12.5 25.3 41.5 48.1 68.4 124.5Control HEXACIDE ™  4 qts 3.9 3.6 5.9 7.8 21.6 34.9 Agri-Mek ® 32 oz17.2 10.1 7.6 11.2 8.6 22.1

Table 10 below shows the effectiveness of HEXACIDE™ Against Pacific MiteTetranychus pacificus on grapes. Means followed by same letter do notsignificantly differ (p=0.05, Duncan's New MRT). DAT=days aftertreatment. Latron B-1956 @ 3 oz/acre used as an adjuvant. Fourreplicates per treatment were performed.

TABLE 10 Number of Live Mites Rate/ Pre- % Treatment Acre treatment 2DAT 7 DAT 14 DAT Control Untreated / 30.0 a 18.0 a  12.8 a  9.0 a /Control HEXACIDE ™   3 qt 28.8 a 4.3 b 2.5 b 0.0 b 100.0 HEXACIDE ™   6qt 24.5 a 4.8 b 2.3 b 1.3 b 85.5 Kelthane 200 2.5 lb 23.5 a 5.0 b 3.8 b0.5 b 94.4

Table 11 below shows the effectiveness of HEXACIDE™ Against Melon AphidsAphis gossypii on squash. Means followed by same letters do notsignificantly differ (p=0.05). Randomized complete block design wasused. Five replicates per treatment were performed. 100 gallons sprayvolume per acre (GPA). Latron CS-7 at 4 ml/gallon was added to alltreatments. All foliar applied pesticidal compositions applied, exceptAdmire and Platinum (soil insecticides). HEXACIDE™, Azadiractin andPyganic applied three times at one week interval. Other products appliedonce.

TABLE 11 Rate/ Mean % Aphids per Leaf Treatment Acre Pretreatment 6 DAT12 DAT Untreated Conrol / 5.5 b 7.8 d 20.8 d HEXACIDE ™ 2 qt 9.7 c 2.8 b 3.9 ab Azadiractin 1 qt 3.9 b 5.4 c 15.1 c Pyganic 1 qt 0.4 b 3.1 b 4.6 b Fulfill 77 g 5.3 b 0.1 a  0.1 a Admire 170 g 0.7 a 0.4 a  0.8 abPlatinum 78 g 0.3 a 0.3 a  1.7 ab Actara 86 g 7.0 bc 0 a  0.1 a Lannate454 g 6.8 b 0 a  0.2 a

The greenhouse and field studies itemized above demonstrate theinvertebrate control observed at various stages of the lifecycle ofplant pests. This extraordinary control is equivalent to that ofconventional synthetic pesticides and is unexpected.

EXAMPLE 3 Pesticidal Effects Against Household Pests

Multiple studies were completed over the course of several monthsutilizing rosemary oil and wintergreen oil with and without variousdiluents as well as conventional pesticides. Insects were observed forimmobilization (IM), knockdown (KD), and mortality. Special focus wasgiven to speed of action of the test chemicals and ratios involvedtherein. Methyl salicylate (MS) was used as wintergreen oil.

Effect on American Cockroaches 24 hrs after arriving from supplier. Testprocedure: Cockroaches are held under screened-cap for spray and thenreleased in open container. Administered 4 squeezes of trigger spray(approximately 3 grams) of test chemical to insect unless otherwisenoted. Insects are monitored for knockdown and mortality. Three insectswere used per test chemical. EcoPCO AC™ was utilized as a positivecontrol. Untreated controls were also utilized. No mortality wasobserved in the untreated controls. Results are shown in Table 12.

TABLE 12 KD Mortality EcoPCO AC formulation No KD 58 s No KD 1 m 07 s NoKD 6 m 07 s 46 g Mineral oil 2 m 30 s >5 m 40 g MS 2 m 17 s >5 m no KD 2m 20 s 40% Mineral oil no KD 45 s 40% MS no KD 30 s 20% Rosemary 14 s 30s 70% Mineral oil 27 s 1 m 10 s 30% MS no KD 43 s no KD 4 m 05 s 30%Mineral oil no KD >5 m 70% MS no KD >5 m no KD 1 m 56 s 20% Mineral oil1 m 32 s >5 m 60% MS 1 m 10 s >5 m 20% Rosemary 1 m 21 s >5 m 50% MS 4 m30 s >5 m 50% Castor oil no KD >5 m 25% MS no KD 38 s 75% Rosemary  8 s13 s (*solution ate through glove) no KD 29 s 50% MS no KD 28 s 50%Rosemary 16 s 36 s 75% MS no KD 24 s 25% Rosemary no KD 42 s 100%Mineral oil - 4 squeezes and release no KD >5 m 100% Rosemary - 4squeezes and release no KD 26 s Note below effects when applied directlyto thorax of insect using Pasteur Pipette: 100% MS - 1 drop 3 m 40 s >5m no KD >5 m no KD >5 m 100% Mineral oil - 1 drop KD @5 m 46 s Mort >7 m“gasping” at 1 m 40 s very lethargic at 3 m 100% Rosemary - 1 drop KD @1 m 55 s mort >5 m neurotoxic signs at 48 s

The data outlined above demonstrates the unique and unexpected efficacyboth in terms of knockdown and mortality using rosemary oil andwintergreen oil. The data clearly indicates that a certain amount ofmineral oil in combination with rosemary oil and wintergreen oilprovides enhanced insecticidal effects using less active ingredients.Various ratios of the proprietary blend (rosemary oil, wintergreen oil,mineral oil) will create knockdown and mortality, but a more preferredblend is 40% wintergreen oil, 40% mineral oil, and 20% rosemary oil.Rosemary is very effective as a direct spray, and causes neurotoxicexcitation upon contact, but is abrasive on surfaces and is also veryexpensive. Wintergreen oil is an effective neurotoxin for mortality andis relatively inexpensive, but is slow acting and has a strongfragrance. Mineral oil is odorless and provides excellent spreadingproperties over the surface of the insect, but is not neurotoxic toinsects and has poor knockdown properties. Rosemary oil and wintergreenoil complement each other's beneficial toxic properties while providingfast acting pesticides that are affordable and aesthetically acceptable.

B) Effects on American Cockroaches. Test procedure: Cockroaches are heldunder screened-cap for spray and then released in open container.Administered 3 squeezes of trigger spray (approximately 2.2 grams) oftest chemical (Table 13) to insect unless otherwise noted. Insects aremonitored for knockdown and mortality. Three to five insects were usedper test chemical. Untreated controls were utilized. No mortality wasobserved in the untreated controls. Results are shown in Table 14.

TABLE 13 E51-1 E51-2 E51-3 E51-4 E51-5 E51-6 E51-7 E51-8 E51-9 Mineraloil 40% 40% 0 30% 30% 20% 20% 15% 10% MS 40% 40% 50% 50% 55% 60% 55% 60%65% PEP 20% 0 20% 15% 10% 15% 15% 15% 15% Cinnamon oil 0 20% 0 0 0 0 0 00 Castor oil 0 0 30% 0 0 0 0 0 0 (yellow) Rosemary 0 0 0  5% 0  5%  5% 5%  5% Sesame oil 0 0 0 0  5% 0 0 0 0 Soybean oil 0 0 0 0 0 0  5%  5% 5% PEP = 2-phenethyl propionate

TABLE 14 IM KD Mortality E51-1 29 s no KD 1 m 34 s no KD 38 s no KD 56 sno KD 35 s 33 s no KD 2 m 09 s *2 trigger sprays 1 m 32 s no KD 1 m 47 sno KD >3 m 1 m 16 s >3 m no KD >3 m E51-2 27 s 1 m 26 s no KD 27 s noKD >3 m E51-3 14 s no KD 28 s no KD >3 m 49 s 1 m 27 s 29 s 1 m 05 sE51-4 7 s 47 s no KD 1 m 13 s 2 m 45 s 2 m 50 s 13 s no KD 1 m 02 s *2trigger sprays 18 s 1 m 15 s 14 s no KD 44 s 47 s no KD 1 m 42 s 1 m 17s 1 m 35 s >3 m 36 s no KD 1 m 14 s E51-5 3 m 00 s >5 m 57 s >5 m 1 m 07s >5 m E51-6 16 s no KD 56 s 1 m 15 s >3 m  9 s no KD 46 s 22 s no KD 1m 02 s *2 trigger sprays 40 s 1 m 32 s 20 s no KD 57 s 15 s no KD 58 sE51-7 16 s no KD 31 s 15 s no KD 52 s 32 s No KD 42 s 6 s 43 s *2trigger sprays 25 s no KD 1 m 10 s 10 s 56 s 41 s 1 m 07 s >3 m (3 m 24s) 1 m 27 s >3 m E51-8 1 m 19 s >3 m 1 m 27 s 2 m 30 s >3 m 10 s 48 s 29s 1 m 02 s 1 m 09 s 2 m 29 s >3 m *2 trigger sprays no KD >3 m 58 s noKD 2 m 02 s 1 m 30 s >3 m E51-9 52 s no KD 3 m 26 s 11 s no KD 46 s 15 sno KD 1 m 14 s no KD 48 s *2 trigger sprays 10 s no KD 2 m 33 s 14 s noKD 1 m 14 s 1 m 18 s no KD >3 m 13 s no KD 1 m 00 s 2 m 20 s >3 m 55 sno KD 2 m 25 s 40% MS 1 m 43 s no KD >3 m 40% Mineral Oil 15 s no KD 54s 20% Rosemary 17 s no KD 58 s (3-blend) 16 s no KD 33 s *2 triggersprays 11 s 39 s adl2-4-122a no KD >3 m (25% 3-blend in water) no KD >3m no KD >3 m adl2-4-122b 31 s no KD 52 s (50% 3-blend in water) 27 s noKD 49 s 1 m 23 s 1 m 31 s >3 m 37 s no KD 1 m 12 s

The data presented above exhibits the necessity of rosemary oil to offerfast action. Further, the data demonstrates the ability to add variousdiluents such as mineral oil, soybean oil and sesame oil, as well asvarious conventional pesticides such as 2-phenethyl propionate, tocreate desirable formulations containing rosemary oil and wintergreenoil. Several formulations perform quite well at higher dosage rates, butthe proprietary blend of rosemary oil and wintergreen oil with mineraloil (3-blend) is most toxic at lower dosage rates. The speed of actionin terms of immobilization and mortality are unexpected and offerdistinct safety advantages over other conventional synthetic pesticides.

C) Testing performed on American Cockroaches. Test procedure:Cockroaches are held under screened-cap for spray and then released inopen container. Administered 2 squeezes of trigger spray (approximately1.5 grams) of test chemical (Table 15) to insect unless otherwise noted.Insects are monitored for knockdown and mortality. Two insects were usedper test chemical. Untreated controls were utilized. No mortality wasobserved in the untreated controls. Results are shown in Table 16.

TABLE 15 001012-1 001012-2 001012-3 PEP 20% 15% 0 Eugenol 0  5% 20%Sesame oil  5% 0  5% Soybean oil  5%  5%  5% MS 35% 40% 35% Saffloweroil 35% 35% 35%

TABLE 16 IM KD Mortality 001012-1 40 s — 51 s — 2 m 28 s >3 m 001012-221 s — 54 s — 22 s 44 s 001012-3 15 s — 39 s 2 m 05 s 2 m 40 s >3 m

Testing on German Cockroaches sprayed with 1-trigger spray in large opencontainer. Three insects per test chemical. Test chemicals identifiedabove. Results are shown in Table 17.

TABLE 17 IM KD Mortality E51-4 12 s — 32 s — 19 s 32 s 28 s — 42 s E51-611 s — 17 s 13 s — 18 s 15 s — 17 s E51-9  4 s — 19 s —  8 s 15 s  9 s —17 s 3-blend  6 s — 15 s —  9 s 15 s —  9 s 15 s 001012-1 —  5 s 15 s  9s — 20 s — 12 s 30 s 001012-2 — 12 s 37 s 20 s — 30 s — 28 s 33 s (finemist) 48 s — 2 m 10 s (walk-across) — 22 s 1 m 20 s 001012-3 — 10 s 32 s— 1 m 04 s 1 m 14 s — 42 s 2 m 42 s

This data shows that German cockroaches are highly sensitive topesticidal compositions of the present invention, requiring less dosagerates, even on walk across exposure trials.

Testing of houseflies sprayed 1-trigger spray into jar.

E51-9 12/12 instant KD and mortality <30 s 17/17 instant KD andmortality <30 s

Testing performed on American Cockroaches. Test procedure: Cockroachesare held under screened-cap (with 10×10 cm plastic matting) for sprayand then released in open container. Administered 2 squeezes of triggerspray (approximately 1.5 grams) of test chemical (Tables 18 and 19) toinsect unless otherwise noted. Insects are monitored for knockdown andmortality. Two to six insects were used per test chemical. Untreatedcontrols were utilized. No mortality was observed in the untreatedcontrols. Results shown in Table 20.

TABLE 18 E51-9B = 001018-4 E51-9C 001012-3A 15% PEP 15% Thyme oil 15%Eugenol 5% RM 5% RM 5% Sesame oil 50% MS 50% MS 5% Soybean oil 25%Mineral oil 25% mineral oil 50% MS 20% Mineral oil

TABLE 19 001027-1 001027-2 001027-3 001027-4 001027-5 001027-6 PEP 15%15% 20% 15% Eugenol  5% — — 20% — — Rosemary —  5% — —  5%  5% Soybeanoil — — — — —  5% MS 50% 50% 50% 50% 50% 50% Safflower oil 20% 20% 20%20% 20% 15% Mineral oil — 10% 10% 10% 10% 10% Thyme oil — — — — 15% —

TABLE 20 IM KD Mortality E51-9B (=001018-4) 9 s 15 s 33 s — 38 s 50 s —15 s 1 m 07 s 11 s — 34 s E51-9C — 7 s 15 s — 5 s 18 s — 17 s 42 s001012-3A — 10 s 21 s 50 s 1 m 10 s 1 m 40 s 27 s — 1 m 01 s — 53 s 1 m11 s 001027-1 — — >2 m — 20 s 44 s — 15 s 33 s — — >2 m 13 s 17 s 25 s10 s — 26 s 001027-2 19 s 33 s 1 m 18 s — 16 s 28 s 10 s 18 s 25 s 16 s— 30 s 001027-3 — 11 s 37 s — 12 s 46 s 16 s 21 s 42 s 10 s — 29 s001027-4 — 29 s 44 s — 6 s 24 s 28 s 47 s 1 m 11 s — 11 s 28 s 001027-511 s — 23 s 47 s 1 m 07 s 1 m 28 s — 12 s 29 s — 6 s 25 s 001027-6(1-spray) — — >2 m 12 s 19 s 45 s 7 s — 31 s — 12 s 30 s 12 s — 25 s

The data presented above demonstrates the speed at which pesticidalcompositions of the present invention act.

EXAMPLE 4

The following formulation (DR-A-041) was tested as an effective broadfoliar fungicide in agriculture, vegetable, fruits, turf andornamentals:

Rosemary Oil 16.36% w/w Wintergreen Oil 73.64% w/w Rhodafac RE 61010.00% w/w(Rhodafac RE 610 is sold by Rhodia, Cranbury N.J.). The results areshown in Tables 21-23 and FIG. 12.

Table 21 shows the effectiveness of DR-A-041 Experimental FungicideAgainst Powdery Mildew Uncinula necator on Grapes. Randomized completeblock design, 3 replicates, 4-5 applications/treatment @ 14-21 daysintervals during pre-bloom to veraison

125 gallons spray volume/acre (GPA). Means followed by the same letterare not significantly different according to Fisher LSD t-test atp=0.05. Results were Log (x+1) transformed prior to statistical analysisdue to heterogeneity of variance.

TABLE 21 Rate/ % Average Disease % Diseased Treatment Acre Severity onfruits Cluster Untreated Control / 24.9 a 60.0 a DR-A-041 0.5 lb  3.2 ab28.1 b Elite 4 oz  0.9 bc 11.4 c Rubigan 6 oz  0.2 c  4.2 d Flint 2 oz 0.03 dc  1.5 dc

Table 22 shows the effectiveness of DR-A-041 Experimental FungicideAgainst Brown Patch Rhizoctonia solani on Turf. Field Tests. Meansfollowed by the same letters are not significantly different at 0.05level. Randomized complete block design, 4 replicates.

TABLE 22 Plot Diseased Severity: Rate/1000 0 (no disease)-5 (>50%diseased) Treatment sq. ft June 27 July 11 July 24 Untreated Control /1.3 a 3.5 a 3.8 a DR-A-041 2.0 oz 2.3 a 0.3 bc 0.3 bc Eagle G 8.0 oz 2.3a 1.5 bc 2.5 a Banner MAXX 2.0 oz 1.0 a 0 c 0 c Daconil 82.5 WDG 3.2 oz1.0 a 0 c 0.5 bc Banner MAXX 1.3 MEC 1.0 oz + + 1.3 a 0 c 0.3 bc PrimoMAXX 2.0 oz

Table 23 shows the effectiveness of DR-A-041 Experimental FungicideAgainst Dollar Spot Sclerotinia homoeocarpa on Turf. Means followed bythe same letters are not significantly different at 0.05 level.Randomized complete block design, 4 replicates.

TABLE 23 Rate/1000 % Plot Diseased Severity Treatment sq. ft June 27July 11 July 24 Untreated Control /  3.3 a 10.3 b  9.3 ab DR-A-041 2.0oz  4.5 a  2.3 d  0.8 c Eagle G 8.0 oz 12.5 a 20.1 a 14.0 a Banner MAXX2.0 oz  2.5 a  7.5 bd  8.1 ab Daconil 82.5 WDG 3.2 oz  8.9 a  1.2 d  0 cBanner MAXX 1.3 MEC 1.0 oz + +  1.3 a  0 c  0.3 bc Primo MAXX 2.0 oz

As can be seen from the above discussion, the pesticidal combinations ofactive compounds according to the present invention are markedlysuperior to known pesticidal agents/active compounds conventionally usedfor control of invertebrate pests.

Although illustrative embodiments of the invention have been describedin detail, it is to be understood that the present invention is notlimited to those precise embodiments, and that various changes andmodifications can be effected therein by one skilled in the art withoutdeparting from the scope and spirit of the invention as defined by theappended claims.

What is claimed is:
 1. A spray container consisting essentially of:rosemary oil in an amount of from 0.001 to 2% by weight, peppermint oilin an amount of from 0.001 to 2% by weight, cinnamon oil in an amount offrom 0.001 to 2% by weight, sesame oil in an amount of from 0.001 to 2%by weight, thyme oil in an amount of from 0.001 to 2% by weight, soybeanoil in an amount of from 0.0001 to 10% by weight, and wintergreen oil inan amount of from 0.0001 to 10% by weight.
 2. The spray container ofclaim 1 further consisting essentially of at least one member selectedfrom the group consisting of bentonite, calcium carbonate, cellulose,clove, dolomite, kaolin, lecithin, mustard and water.
 3. The spraycontainer of claim 1 further consisting essentially of at least onemember selected from the group consisting of mineral oil, benzylalcohol, citronellal, d-limonene and safflower oil.